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Got2 Gene Detail
 Symbol
Name
ID
Got2
glutamate oxaloacetate transaminase 2, mitochondrial
MGI:95792

Nomenclature History
Synonyms FABP-pm, Got-2, mAspAT, mitochondrial aspartate aminotransferase, plasma membrane fatty acid binding protein
Genetic Map
Chromosome 8
46.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 22)

Sequence Map
Chr8:98388034-98412447 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; horse; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Got2 ± 2 cM)
Protein SuperFamily: aspartate aminotransferase/aromatic aminotransferase, tatA type
TreeFam: TF300641
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016488 VEGA Gene Model | MGI Sequence Detail 24414 C57BL/6J ± Kb
transcript NM_010325 RefSeq | MGI Sequence Detail 2345 C57BL/6
polypeptide P05202 UniProt | EBI | MGI Sequence Detail 430 Not Applicable
For the selected sequences
All sequences(55)
Alleles
and
phenotypes 		All alleles(1) : Gene trapped(1)
Polymorphisms PCR(1) SNPs within 2kb(95 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(19)
Process aspartate biosynthetic process, biosynthetic process...
Component membrane, mitochondrial inner membrane...
Function catalytic activity, L-aspartate:2-oxoglutarate aminotransferase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (14)    Tissues (8)    Images (5)
Theiler Stages: 24,28
  Assay Type Assays   Results
      RNA in situ 1   14
cDNA source data(16)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(25) Genomic(4) cDNA(20) Primer pair(1)
Microarray probesets(5)
Pathways
aspartate degradation I
aspartate biosynthesis
L-cysteine degradation I
glutamine degradation II
glutamate degradation VII
superpathway of methionine degradation
Other database
links
EC 2.6.1.1
Ensembl Gene Model ENSMUSG00000031672
DoTS DT.40176591, DT.496222, DT.91400286, DT.94213614
DFCI TC1573816, TC1612367, TC1720158
NIA Mouse Gene Index U026870, U030142
Entrez Gene 14719
VEGA Gene Model OTTMUSG00000016488
International Mouse Knockout Project Status Got2
Protein
domains
InterPro ID Description
IPR000796 Aspartate/other aminotransferase
IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site
IPR004839 Aminotransferase, class I/II
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
Graphical View of Protein Domain Structure
References
(Earliest) J:5163 DeLorenzo RJ et al., "Glutamate oxalate transaminase (GOT) genetics in Mus musculus: linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci." Biochem Genet 1970 Apr;4(2):259-73
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(33)
Other
accession IDs 		MGD-MRK-10214, MGD-MRK-10216, MGI:2142656
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
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