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Gnat2 Gene Detail
 Symbol
Name
ID
Gnat2
guanine nucleotide binding protein, alpha transducing 2
MGI:95779


Nomenclature History
Synonyms Gnat-2, Gt-2, Tcalpha
Genetic Map
Chromosome 3
49.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr3:107895707-107904350 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; hamster, Chinese; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Gnat2 ± 2 cM)
Protein SuperFamily: GTP-binding regulatory protein Gs alpha chain
TreeFam: TF300673
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000007183 VEGA Gene Model | MGI Sequence Detail 8644 C57BL/6J ± Kb
transcript NM_008141 RefSeq | MGI Sequence Detail 1643 -
polypeptide P50149 UniProt | EBI | MGI Sequence Detail 354 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes
All alleles(4) : Gene trapped(3) Spontaneous(1)
Mutations in this gene result in progressive degeneration of photoreceptors and normal ERG responses.
Polymorphisms RFLP(1) SNPs within 2kb(36 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(19)
Process detection of light stimulus involved in visual perception, G-protein coupled receptor protein signaling pathway...
Component heterotrimeric G-protein complex, membrane fraction...
Function GTP binding, GTPase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (12)    Tissues (10)    Images (5)
Theiler Stages: 1,2,3,4,28
  Assay Type Assays   Results
      RT-PCR 1   10
      RNA in situ 1   2
cDNA source data(22)
External Resources: GENSAT  GEO 
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(23) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000009108
DoTS DT.101706881, DT.40167180, DT.91355122
UniGene 439652
DFCI TC1585090, TC1623865
NIA Mouse Gene Index U003724
Entrez Gene 14686
VEGA Gene Model OTTMUSG00000007183
International Mouse Knockout Project Status Gnat2
Protein
domains
InterPro ID Description
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR011025 G protein alpha subunit, helical insertion
Graphical View of Protein Domain Structure
References
(Earliest) J:30928 Lochrie MA et al., "Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors." Science 1985 Apr 5;228(4695):96-9
(Latest) J:153749 Deng WT et al., "Functional interchangeability of rod and cone transducin alpha-subunits." Proc Natl Acad Sci U S A 2009 Oct 20;106(42):17681-6
All references(21)
Other
accession IDs
MGD-MRK-10191, MGD-MRK-10193, MGI:2139985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory