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Glo1 Gene Detail
 Symbol
Name
ID
Glo1
glyoxalase 1
MGI:95742

Nomenclature History
Synonyms 0610009E22Rik, 1110008E19Rik, 2510049H23Rik, Glo-1, Glo-1r, Glo-1s, Glo1-r, Glo1-s, Qglo
Genetic Map
Chromosome 17
16.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 63)

Sequence Map
Chr17:30729806-30749539 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; hamster, Chinese; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Glo1 ± 2 cM)
TreeFam: TF105011
Sequences
Representative Sequences Length Strain/Species Flank
genomic 109801 NCBI Gene Model | MGI Sequence Detail 19734 C57BL/6J ± Kb
transcript NM_025374 RefSeq | MGI Sequence Detail 1958 C57BL/6
polypeptide Q9CPU0 UniProt | EBI | MGI Sequence Detail 184 Not Applicable
For the selected sequences
All sequences(38)
Alleles
and
phenotypes 		All alleles(51) : Gene trapped(51)
This locus controls electrophoretic mobility and activity level of erythrocyte GLO1. The a allele produces a fast migrating band seen in AKR, CBA/H and C57BL/6; the b allele, a slow band, in MA/MyJ. At least 6 different activity-determining alleles, designated ra through rf, are found among strains.
Polymorphisms SNPs within 2kb(91 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(5)
Function lactoylglutathione lyase activity, lyase activity...
External Resources: MouseFunc
Expression Literature Summary: (1 records)
Data Summary: Assays (2)    Results (4)    Tissues (2)    Images (4)
Theiler Stages: 28
  Assay Type Assays   Results
      RNA in situ 2   4
cDNA source data(14)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(16) cDNA(15) Other(1)
Microarray probesets(5)
Pathways
methylglyoxal degradation I
Other database
links
EC 4.4.1.5
Ensembl Gene Model ENSMUSG00000024026
DoTS DT.101387967, DT.101713383, DT.110555530, DT.495459
PDB 2ZA0
DFCI TC1573552, TC1591628, TC1695801, TC1697568
NIA Mouse Gene Index U001655, U037639
Entrez Gene 109801
International Mouse Knockout Project Status Glo1
Protein
domains
InterPro ID Description
IPR004360 Glyoxalase/bleomycin resistance protein/dioxygenase
IPR004361 Glyoxalase I
IPR018146 Glyoxalase I, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:5879 Meo T et al., "Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2." Science 1977 Oct 21;198(4314):311-3
(Latest) J:147375 Williams R th et al., "A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior." PLoS ONE 2009;4(3):e4649
All references(49)
Other
accession IDs 		MGD-MRK-10120, MGD-MRK-10121, MGD-MRK-10122, MGD-MRK-10124, MGD-MRK-10125, MGD-MRK-10126, MGD-MRK-13737, MGI:1913383, MGI:1917563, MGI:1918922, MGI:2147081, MGI:95743, MGI:95744
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory