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Gjb3 Gene Detail
 Symbol
Name
ID
Gjb3
gap junction protein, beta 3
MGI:95721


Nomenclature History
Synonyms Cnx31, connexin 31, Cx31, D4Wsu144e, Gjb-3
Genetic Map
Chromosome 4
58.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr4:127002479-127008088 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Gjb3 ± 2 cM)
Protein SuperFamily: gap junction protein
TreeFam: TF329606
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000009382 VEGA Gene Model | MGI Sequence Detail 5610 C57BL/6J ± Kb
transcript NM_001160012 RefSeq | MGI Sequence Detail 1886 C57BL/6
polypeptide P28231 UniProt | EBI | MGI Sequence Detail 270 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes
All alleles(73) : Targeted, other(3) Gene trapped(70)
Homozygous null mice exhibit partial lethality and transient placental dysmorphogenesis but no impairment in hearing or skin differentiation.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(41 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(9)
Process cell communication, placenta development...
Component cell junction, connexon complex...
Function protein binding
External Resources: MouseFunc
Expression Literature Summary: (16 records)
Data Summary: Assays (4)    Results (13)    Tissues (7)    Images (2)
Theiler Stages: 13,20,25,28
  Assay Type Assays   Results
      RT-PCR 4   13
cDNA source data(63)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(67) cDNA(63) Primer pair(4) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000042367
DoTS DT.110833969, DT.40185449, DT.491166
UniGene 90003
DFCI TC1577602, TC1622455, TC1748864
NIA Mouse Gene Index U025533
Entrez Gene 14620
VEGA Gene Model OTTMUSG00000009382
International Mouse Knockout Project Status Gjb3
Protein
domains
InterPro ID Description
IPR000500 Connexins
IPR002269 Gap junction beta-3 protein (Cx31)
IPR013092 Connexin, N-terminal
IPR017990 Connexin, conserved site
IPR017991 Connexin region
IPR019570 Gap junction protein, cysteine-rich domain
Graphical View of Protein Domain Structure
References
(Earliest) J:858 Willecke K et al., "The diversity of connexin genes encoding gap junctional proteins." Eur J Cell Biol 1991 Oct;56(1):1-7
(Latest) J:152946 Sferruzzi-Perri AN et al., "Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice." Biol Reprod 2009 Jul;81(1):207-21
All references(34)
Other
accession IDs
MGD-MRK-10093, MGD-MRK-10098, MGD-MRK-35792, MGI:107326

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory