Symbol
Name
ID
|
|
|
STS
|
D14Mit83
|
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Synonyms
|
connexin 26, Cx26, Gjb-2
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Genetic Map
|
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Sequence Map
|
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Mammalian
homology
|
|
|
Sequences
|
All sequences(28)
|
Alleles
and
phenotypes
|
All alleles(6) :
Targeted, knock-out(1)
Targeted, other(2)
Chemically induced(3)
| Mutant homozygotes are developmentally retarded with impaired transplacental nutrient/glucose uptake and die about embryonic day 11. Conditional mutants in inner ear are hearing impaired with cell death in cochlear epithelial network and inner hair cells. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
Phenotype Images (2)
|
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Polymorphisms
|
RFLP(1)
SNPs within 2kb(48 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (31 records)
Data Summary:
Assays (20)
Results (92)
Tissues (52)
Images (19)
Theiler Stages: 1,7,9,11,15,19,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
4 |
|
13 |
| |
Immunohistochemistry |
1 |
|
5 |
| |
Nuclease S1 |
14 |
|
66 |
| |
Northern blot |
1 |
|
8 |
cDNA source data(103)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(113)
Genomic(6)
cDNA(104)
Primer pair(3)
Antibodies(1)
Microarray probesets(2)
|
Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
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References
|
(Earliest)
J:11099
Hsieh CL et al.,
"Distribution of genes for gap junction membrane channel proteins on human and mouse chromosomes."
Somat Cell Mol Genet 1991 Mar;17(2):191-200
(Latest)
J:150813
Dupressoir A et al.,
"Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene."
Proc Natl Acad Sci U S A 2009 Jul 21;106(29):12127-32
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All references(78)
|
Other
accession IDs
|
MGD-MRK-10092, MGD-MRK-10097, MGI:2145620
|
