Fgfr2 MGI Mouse Gene Detail - MGI:95523 - fibroblast growth factor receptor 2

Fgfr2 Gene Detail

Symbol
Name
ID

Fgfr2
fibroblast growth factor receptor 2
MGI:95523

Synonyms

Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFRTr, svs

Genetic Map

Chromosome 7
62.0 cM
Detailed Genetic Map ± 1 cM

Mapping data( 14)

Sequence Map

Chr7:137305965-140315033 bp, - strand

(From VEGA annotation of NCBI Build 37)

VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian
homology

human; chimpanzee; cattle; dog, domestic; rat (Mammalian Orthology)

Comparative Map (Mouse/Human Fgfr2 ± 2 cM)

Protein SuperFamily: fibroblast growth factor receptor

TreeFam: TF316307

Sequences

All sequences(74)

Alleles
and
phenotypes

All alleles(91) : Targeted, knock-out(11) Targeted, other(12) Gene trapped(67) Spontaneous(1)

Mice homozygous for null mutations die as embryos. Isoform IIIb deficient mutants die at birth with defects in multiple organs and tissues. Isoform IIIc deficient mutants have defects in osteoblast and chondrocyte lineages, producing dwarfism.

Associated Human Diseases (4) Alleles Annotated to Human Diseases (6) Phenotype Images (15)

Polymorphisms

RFLP(2) SNPs within 2kb(13347 from dbSNP Build 128) SNPs within 2kb including multiple locations(13385)

Gene Ontology
(GO)
classifications

All GO classifications(87)
Process	angiogenesis, bone mineralization...
Component	extracellular region, integral to membrane...
Function	ATP binding, fibroblast growth factor binding...
External Resources: MouseFunc

Expression

Literature Summary: (203 records)
Data Summary: Assays (64) Results (589) Tissues (300) Images (170)
Theiler Stages: 2,3,4,5,6,8,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,28

Assay Type	Assays	Results
RT-PCR	30	172
RNA in situ	29	385
Immunohistochemistry	4	28
Northern blot	1	4

cDNA source data(878)
External Resources: Allen Brain Atlas GENSAT GEO

Molecular
reagents

All nucleic(921) Genomic(3) cDNA(884) Primer pair(21) Other(13) Antibodies(4)
Microarray probesets(3)

Other database
links

EC	2.7.10.1
Ensembl Gene Model	ENSMUSG00000030849
DoTS	DT.101365770, DT.101740973, DT.528387, DT.94146700, DT.94159570, DT.94159579, DT.94297839
UniGene	16340
NIA Mouse Gene Index	U029330
Entrez Gene	14183
VEGA Gene Model	OTTMUSG00000031222
International Mouse Knockout Project Status	Fgfr2

Protein
domains

InterPro ID	Description
IPR000719	Protein kinase, catalytic domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR003598	Immunoglobulin subtype 2
IPR007110	Immunoglobulin-like
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain
IPR013098	Immunoglobulin I-set
IPR013151	Immunoglobulin
IPR013783	Immunoglobulin-like fold
IPR016248	Tyrosine-protein kinase, fibroblast growth factor receptor
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Graphical View of Protein Domain Structure

References

(Earliest) J:9441 Shukri NM et al., "Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shape." Genet Res 1988 Aug;52(1):27-32
(Latest) J:153975 Sims-Lucas S et al., "Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia." Am J Physiol Renal Physiol 2009 Nov;297(5):F1208-19

All references(305)

Other
accession IDs

MGD-MRK-14668, MGD-MRK-1537, MGD-MRK-9777, MGD-MRK-9780, MGD-MRK-9782, MGD-MRK-9785, MGI:2142159, MGI:2142264, MGI:98454

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/20/2009 MGI_4.31 Web browser compatibility