Symbol
Name
ID
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Synonyms
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D18Wsu70e, DPC4, Dpc4, Madh4, Smad 4
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(27)
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Alleles
and
phenotypes
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All alleles(33) :
Targeted, knock-out(7)
Targeted, other(4)
Gene trapped(17)
Spontaneous(1)
Chemically induced(4)
| Homozygotes for targeted null mutations exhibit impaired formation of extraembryonic membrane and endoderm and die prior to gastrulation. Heterozygotes develop polyposis of the glandular stomach and duodenum. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
Phenotype Images (2)
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Polymorphisms
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RFLP(1)
SNPs within 2kb(284 from dbSNP Build 128)
SNPs within 2kb including multiple locations(296)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (39 records)
Data Summary:
Assays (14)
Results (109)
Tissues (82)
Images (4)
Theiler Stages: 2,3,4,5,9,11,13,17,20,21,22,23,24,26,28
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Assay Type |
Assays |
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Results |
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Western blot |
2 |
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9 |
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RT-PCR |
3 |
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27 |
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RNA in situ |
6 |
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54 |
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Northern blot |
3 |
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19 |
cDNA source data(14)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
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All nucleic(27)
Genomic(5)
cDNA(17)
Primer pair(4)
Other(1)
Antibodies(2)
Microarray probesets(4)
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Other database
links
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Protein
domains
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Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:40660
Anna CH et al.,
"Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene."
Mamm Genome 1997 Jun;8(6):443-4
(Latest)
J:156253
Tateossian H et al.,
"Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant."
Pathogenetics 2009;2(1):5
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All references(157)
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Other
accession IDs
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MGD-MRK-33955, MGI:106263, MGI:2147379
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Analysis Tools
MGI BioMart
