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Sfrp1 Gene Detail
 Symbol
Name
ID
Sfrp1
secreted frizzled-related protein 1
MGI:892014

Nomenclature History
Synonyms 2210415K03Rik, sFRP-1
Genetic Map
Chromosome 8
9.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr8:24521974-24560104 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Sfrp1 ± 2 cM)
Protein SuperFamily: secreted frizzled-related protein
TreeFam: TF350133
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021102 VEGA Gene Model | MGI Sequence Detail 38131 C57BL/6J ± Kb
transcript NM_013834 RefSeq | MGI Sequence Detail 4389 C57BL/6
polypeptide Q8C4U3 UniProt | EBI | MGI Sequence Detail 314 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes 		All alleles(5) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1) Chemically induced(1)
Homozygous null mice are fertile and display increased trabecular bone area, decreased brain weights, slight hematological abnormalities in males, and increased heart weight in females.
Polymorphisms RFLP(1) SNPs within 2kb(103 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process anterior/posterior pattern formation, cell differentiation...
Component extracellular region
Function protein binding, Wnt-protein binding...
External Resources: FuncBase
Expression Literature Summary: (43 records)
Data Summary: Assays (16)    Results (186)    Tissues (152)    Images (59)
Theiler Stages: 4,5,8,9,10,11,12,13,15,17,18,19,20,21,22,23,25,26,28
  Assay Type Assays   Results
      Western blot 2   7
      RT-PCR 6   29
      In situ reporter (knock in) 1   18
      RNA in situ 7   132
cDNA source data(160)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(172) cDNA(161) Primer pair(9) Other(2) Antibodies(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000031548
DoTS DT.50316678
Consensus CDS Project CCDS22191.1
UniGene 281691
DFCI TC1576903, TC1713224, TC1735553
NIA Mouse Gene Index U042893
Entrez Gene 20377
VEGA Gene Model OTTMUSG00000021102
International Mouse Knockout Project Status Sfrp1
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR001134 Netrin domain
IPR008993 TIMP-like, OB-fold
IPR015526 Frizzled related
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:39275 Rattner A et al., "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors." Proc Natl Acad Sci U S A 1997 Apr 1;94(7):2859-63
(Latest) J:155074 Agalliu D et al., "Motor neurons with axial muscle projections specified by Wnt4/5 signaling." Neuron 2009 Mar 12;61(5):708-20
All references(56)
Other
accession IDs 		MGI:1919612, MGI:2142743, MGI:2142757, MGI:2142814
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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