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Sfrp4 Gene Detail
 Symbol
Name
ID
Sfrp4
secreted frizzled-related protein 4
MGI:892010

Nomenclature History
Genetic Map
Chromosome 13
7.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr13:19715052-19724690 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Sfrp4 ± 2 cM)
TreeFam: TF317907
Sequences
Representative Sequences Length Strain/Species Flank
genomic 20379 NCBI Gene Model | MGI Sequence Detail 9639 C57BL/6J ± Kb
transcript NM_016687 RefSeq | MGI Sequence Detail 1780 C57BL/6
polypeptide Q9Z1N6 UniProt | EBI | MGI Sequence Detail 351 Not Applicable
For the selected sequences
All sequences(18)
Alleles
and
phenotypes 		All alleles(2) : Gene trapped(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(119 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cell differentiation, multicellular organismal development...
Component extracellular region
Function protein binding, Wnt-protein binding...
External Resources: FuncBase
Expression Literature Summary: (11 records)
Data Summary: Assays (8)    Results (140)    Tissues (117)    Images (25)
Theiler Stages: 5,8,9,11,13,15,17,19,20,21,22,23,26,28
  Assay Type Assays   Results
      Western blot 1   2
      RT-PCR 1   5
      RNA in situ 3   107
      Northern blot 3   26
cDNA source data(18)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(26) Genomic(1) cDNA(18) Primer pair(5) Other(2) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021319
DoTS DT.526602, DT.94277820
Consensus CDS Project CCDS26261.1
UniGene 42095
DFCI TC1581600
NIA Mouse Gene Index U014586
Entrez Gene 20379
International Mouse Knockout Project Status Sfrp4
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR001134 Netrin domain
IPR008993 TIMP-like, OB-fold
IPR015526 Frizzled related
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:39275 Rattner A et al., "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors." Proc Natl Acad Sci U S A 1997 Apr 1;94(7):2859-63
(Latest) J:152099 Bi Y et al., "Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells." J Cell Biochem 2009 Jun 26;108(1):295-303
All references(18)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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