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Ctsl Gene Detail
 Symbol
Name
ID
Ctsl
cathepsin L
MGI:88564

Nomenclature History
Synonyms 1190035F06Rik, Cat L, major excreted protein, MEP
Genetic Map
Chromosome 13
30.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr13:64465105-64471614 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ctsl ± 2 cM)
Protein SuperFamily: papain
TreeFam: TF313739
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000021477 Ensembl Gene Model | MGI Sequence Detail 6510 C57BL/6J ± Kb
transcript NM_009984 RefSeq | MGI Sequence Detail 1971 C57BL/6
polypeptide P06797 UniProt | EBI | MGI Sequence Detail 334 Not Applicable
For the selected sequences
All sequences(56)
Alleles
and
phenotypes 		All alleles(8) : Targeted, knock-out(2) Gene trapped(4) Spontaneous(1) Radiation induced(1)
Homozygotes for mutant alleles may exhibit partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.
Phenotype Images (3)  
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(65 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process proteolysis
Component lysosome
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity...
External Resources: FuncBase
Expression Literature Summary: (14 records)
Data Summary: Assays (14)    Results (175)    Tissues (125)    Images (13)
Theiler Stages: 11,13,15,17,19,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 3   6
      RT-PCR 1   2
      RNA in situ 3   99
      Immunohistochemistry 1   5
      Northern blot 2   29
      RNase protection 4   34
cDNA source data(858)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(864) cDNA(859) Primer pair(4) Other(1) Antibodies(1)
Microarray probesets(2)
Other database
links
EC 3.4.22.14, 3.4.22.15
Ensembl Gene Model ENSMUSG00000021477
DoTS DT.101399618, DT.101715220, DT.87073640, DT.91346359, DT.97371455
Consensus CDS Project CCDS26600.1
UniGene 930
PDB 1MVV
DFCI TC1573717, TC1687750
NIA Mouse Gene Index U034911
Entrez Gene 13039
International Mouse Knockout Project Status Ctsl
Protein
domains
InterPro ID Description
IPR000169 Peptidase, cysteine peptidase active site
IPR000668 Peptidase C1A, papain C-terminal
IPR013128 Peptidase C1A, papain
IPR013201 Proteinase inhibitor I29, cathepsin propeptide
Graphical View of Protein Domain Structure
References
(Earliest) J:15332 Green EL, "The genetics of a new hair deficiency, furless, in the house mouse" J Hered 1954;45():115-18
(Latest) J:153812 Sugita S et al., "Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions." J Immunol 2009 Oct 15;183(8):5013-22
All references(90)
Other
accession IDs 		MGD-MRK-2248, MGD-MRK-9874, MGI:1338075, MGI:2443888, MGI:95581
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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