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Ctla4 Gene Detail
 Symbol
Name
ID
Ctla4
cytotoxic T-lymphocyte-associated protein 4
MGI:88556

Nomenclature History
Synonyms Cd152, Ctla-4, Ly-56
Genetic Map
Chromosome 1
30.1 cM, cytoband C
Detailed Genetic Map ± 1 cM
 
Mapping data( 46)

Sequence Map
Chr1:60943844-60972676 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; rabbit, European; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Ctla4 ± 2 cM)
Protein SuperFamily: T-cell surface glycoprotein CD28
TreeFam: TF335679
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000002278 VEGA Gene Model | MGI Sequence Detail 28833 C57BL/6J ± Kb
transcript NM_009843 RefSeq | MGI Sequence Detail 1931 C57BL/6
polypeptide P09793 UniProt | EBI | MGI Sequence Detail 223 Not Applicable
For the selected sequences
All sequences(27)
Alleles
and
phenotypes 		All alleles(6) : Targeted, knock-out(3) Targeted, other(2) Gene trapped(1)
Polymorphisms All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs within 2kb(144 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process immune response
Component external side of plasma membrane, integral to membrane...
External Resources: FuncBase
Expression cDNA source data(17)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(22) Genomic(3) cDNA(18) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000026011
DoTS DT.40181215, DT.99854682
Consensus CDS Project CCDS14993.1
UniGene 390
PDB 1DQT
DFCI TC1584855, TC1758846
NIA Mouse Gene Index U000349
Entrez Gene 12477
VEGA Gene Model OTTMUSG00000002278
International Mouse Knockout Project Status Ctla4
Protein
domains
InterPro ID Description
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR008096 Cytotoxic T-lymphocyte antigen 4
IPR013106 Immunoglobulin V-set
IPR013783 Immunoglobulin-like fold
Graphical View of Protein Domain Structure
References
(Earliest) J:8775 Brunet JF et al., "A new member of the immunoglobulin superfamily--CTLA-4." Nature 1987 Jul 16-22;328(6127):267-70
(Latest) J:153599 Araki M et al., "Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice." J Immunol 2009 Oct 15;183(8):5146-57
All references(171)
Other
accession IDs 		MGD-MRK-2224, MGD-MRK-2234
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory