Symbol
Name
ID
|
|
|
STS
|
D17Mit16,D17Mit62,D17Mit63,D17Mit82,D17Rua3
|
|
Synonyms
|
Acry-1, alpha-A-crystallin, Crya-1, Crya1, DAcry-1
|
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Genetic Map
|
|
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Sequence Map
|
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Mammalian
homology
|
|
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Sequences
|
All sequences(23)
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Alleles
and
phenotypes
|
All alleles(6) :
Targeted, knock-out(1)
Targeted, other(1)
Spontaneous(2)
Chemically induced(2)
| Homozygotes for a targeted null mutation have small lenses that develop progressive opacity beginning in the nucleus. Homozygotes for spontaneous or ENU-induced mutations have normal sized lenses with a white nuclear cataract by weaning age that expands progressively. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (3)
Phenotype Images (5)
|
|
Polymorphisms
|
RFLP(17)
SNPs within 2kb(52 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (45 records)
Data Summary:
Assays (12)
Results (134)
Tissues (72)
Images (18)
Theiler Stages: 13,15,16,17,18,19,20,22,23,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
5 |
|
26 |
| |
RNA in situ |
5 |
|
98 |
| |
Immunohistochemistry |
2 |
|
10 |
cDNA source data(157)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(172)
Genomic(7)
cDNA(158)
Primer pair(4)
Other(3)
Antibodies(2)
Microarray probesets(2)
|
Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:19720
King CR et al.,
"Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron."
Cell 1983 Mar;32(3):707-12
(Latest)
J:152850
Shaham O et al.,
"Pax6 is essential for lens fiber cell differentiation."
Development 2009 Aug;136(15):2567-78
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All references(122)
|
Other
accession IDs
|
MGD-MRK-1071, MGD-MRK-2160, MGD-MRK-2162, MGD-MRK-36289, MGD-MRK-8792, MGI:107713, MGI:2146823
|
