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Cd4 Gene Detail
 Symbol
Name
ID
Cd4
CD4 antigen
MGI:88335

Nomenclature History
STS D6Mit24
Synonyms L3T4, Ly-4
Genetic Map
Chromosome 6
60.18 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 26)

Sequence Map
Chr6:124814710-124838239 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cd4 ± 2 cM)
Protein SuperFamily: T-cell surface glycoprotein CD4
TreeFam: TF335974
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000023420 VEGA Gene Model | MGI Sequence Detail 23530 C57BL/6J ± Kb
transcript NM_013488 RefSeq | MGI Sequence Detail 3095 C57BL/6
polypeptide P06332 UniProt | EBI | MGI Sequence Detail 457 Not Applicable
For the selected sequences
All sequences(32)
Alleles
and
phenotypes 		All alleles(18) : Targeted, knock-out(5) Targeted, other(5) Gene trapped(6) Spontaneous(2)
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (2)  
Polymorphisms All PCR and RFLP(8) : PCR(6) RFLP(2) SNPs within 2kb(106 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell adhesion, cell surface receptor linked signal transduction...
Component cell surface, endoplasmic reticulum lumen...
External Resources: FuncBase
Expression Literature Summary: (20 records)
Data Summary: Assays (4)    Results (141)    Tissues (46)    Images (3)
Theiler Stages: 23,26,28
  Assay Type Assays   Results
      RT-PCR 3   138
      Immunohistochemistry 1   3
cDNA source data(33)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(52) Genomic(15) cDNA(33) Primer pair(4) Antibodies(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000023274
DoTS DT.87068508, DT.91436625, DT.94130300
Consensus CDS Project CCDS20535.1
UniGene 2209
DFCI TC1584295, TC1621323, TC1754381
NIA Mouse Gene Index U027855
Entrez Gene 12504
VEGA Gene Model OTTMUSG00000023420
International Mouse Knockout Project Status Cd4
Protein
domains
InterPro ID Description
IPR000973 T-cell surface antigen CD4
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR008424 Immunoglobulin C2-set
IPR013151 Immunoglobulin
IPR013783 Immunoglobulin-like fold
IPR015274 CD4, extracellular
Graphical View of Protein Domain Structure
References
(Earliest) J:5358 Snell GD et al., "Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice." Proc Natl Acad Sci U S A 1973 Apr;70(4):1108-11
(Latest) J:152836 Sarafova SD et al., "Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice." Immunity 2009 Sep 18;31(3):480-90
All references(375)
Other
accession IDs 		MGD-MRK-11981, MGD-MRK-1858
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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