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Ccnd2 Gene Detail
 Symbol
Name
ID
Ccnd2
cyclin D2
MGI:88314

Nomenclature History
Synonyms 2600016F06Rik, cD2, Vin-1, Vin1
Genetic Map
Chromosome 6
61.1 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 10)

Sequence Map
Chr6:127080253-127101046 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ccnd2 ± 2 cM)
Protein SuperFamily: cyclin, A/B/D/E types
TreeFam: TF101004
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000000184 Ensembl Gene Model | MGI Sequence Detail 20794 C57BL/6J ± Kb
transcript NM_009829 RefSeq | MGI Sequence Detail 5772 C57BL/6
polypeptide P30280 UniProt | EBI | MGI Sequence Detail 289 Not Applicable
For the selected sequences
All sequences(52)
Alleles
and
phenotypes 		All alleles(1) : Targeted, knock-out(1)
Homozygotes for a targeted null mutation are sterile: females lack a granulosa cell response to follicle stimulating hormone, while males have hypoplastic testes. Mutants also show decreased cerebellar granule cell and stellate neuron populations.
Polymorphisms RFLP(1) SNPs within 2kb(144 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process cell cycle, cell division...
Component nucleus
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (98 records)
Data Summary: Assays (20)    Results (213)    Tissues (172)    Images (39)
Theiler Stages: 14,15,17,18,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 4   12
      RT-PCR 2   48
      RNA in situ 9   132
      Immunohistochemistry 2   8
      Northern blot 3   13
cDNA source data(412)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(443) Genomic(19) cDNA(415) Primer pair(5) Other(4) Antibodies(4)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000000184
DoTS DT.101405514, DT.101405519, DT.103576672, DT.110479076, DT.495919, DT.535688, DT.94349409, DT.97343648
Consensus CDS Project CCDS20564.1
UniGene 333406
DFCI TC1573588, TC1586663, TC1591726, TC1615415, TC1623806, TC1659871
NIA Mouse Gene Index U043852, U201255
Entrez Gene 12444
International Mouse Knockout Project Status Ccnd2
Protein
domains
InterPro ID Description
IPR004367 Cyclin, C-terminal
IPR006670 Cyclin
IPR006671 Cyclin, N-terminal
IPR011028 Cyclin-like
IPR013763 Cyclin-related
IPR014400 Cyclin, A/B/D/E
IPR015451 Cyclin D
Graphical View of Protein Domain Structure
References
(Earliest) J:14776 Matsushime H et al., "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle." Cell 1991 May 17;65(4):701-13
(Latest) J:155057 Hwang DY et al., "Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons." J Neurochem 2009 Dec;111(5):1202-12
All references(146)
Other
accession IDs 		MGD-MRK-15396, MGD-MRK-15397, MGD-MRK-1826, MGI:1353647, MGI:1913821, MGI:2141781, MGI:2683668
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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