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Ccnd1 Gene Detail
 Symbol
Name
ID
Ccnd1
cyclin D1
MGI:88313

Nomenclature History
Synonyms bcl-1, cD1, Cyl-1, PRAD1
Genetic Map
Chromosome 7
72.3 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr7:152115836-152125774 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ccnd1 ± 2 cM)
Protein SuperFamily: cyclin, A/B/D/E types
TreeFam: TF101004
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000026018 VEGA Gene Model | MGI Sequence Detail 9939 C57BL/6J ± Kb
transcript NM_007631 RefSeq | MGI Sequence Detail 3796 C57BL/6
polypeptide P25322 UniProt | EBI | MGI Sequence Detail 295 Not Applicable
For the selected sequences
All sequences(36)
Alleles
and
phenotypes 		All alleles(6) : Targeted, knock-out(3) Targeted, other(3)
Homozygotes for some targeted mutations exhibit reduced body size and viability, impaired retinal development, pregnancy-insensitive mammary glands, and resistance to breast cancer induced by neu and ras oncogenes.
Polymorphisms RFLP(1) SNPs within 2kb(58 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, cell division...
Component cyclin-dependent protein kinase holoenzyme complex, cytosol...
Function cyclin-dependent protein kinase regulator activity, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (179 records)
Data Summary: Assays (42)    Results (292)    Tissues (111)    Images (101)
Theiler Stages: 5,11,14,15,17,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 10   45
      RT-PCR 4   101
      RNA in situ 8   43
      Immunohistochemistry 9   46
      Northern blot 11   57
cDNA source data(21)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(43) Genomic(9) cDNA(23) Primer pair(4) Other(7) Antibodies(10)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000070348
DoTS DT.101206853, DT.101375555, DT.489424
Consensus CDS Project CCDS22055.1
DFCI TC1573542, TC1576383
NIA Mouse Gene Index U068737
Entrez Gene 12443
VEGA Gene Model OTTMUSG00000026018
International Mouse Knockout Project Status Ccnd1
Protein
domains
InterPro ID Description
IPR004367 Cyclin, C-terminal
IPR006670 Cyclin
IPR006671 Cyclin, N-terminal
IPR011028 Cyclin-like
IPR013763 Cyclin-related
IPR014400 Cyclin, A/B/D/E
IPR015451 Cyclin D
Graphical View of Protein Domain Structure
References
(Earliest) J:14776 Matsushime H et al., "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle." Cell 1991 May 17;65(4):701-13
(Latest) J:155594 Lu BC et al., "Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis." Nat Genet 2009 Dec;41(12):1295-302
All references(286)
Other
accession IDs 		MGD-MRK-1825, MGI:2141923
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory