Symbol
Name
ID
|
|
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Synonyms
|
alpha(1B), Cav2.2, Cchn1a
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Genetic Map
|
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(26)
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Alleles
and
phenotypes
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All alleles(4) :
Targeted, knock-out(1)
Targeted, other(3)
| Mice deficient in this gene exhibit defects in nociception, memory and learning. They also exhibit hyperactive and hyperaggressive behaviors as well as defects in the the sleep-wake cycle. Deficits in the sympathetic nervous system results in defects in circulatory regulation. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(883 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
|
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Expression
|
Literature Summary: (6 records)
Data Summary:
Assays (2)
Results (4)
Tissues (4)
Theiler Stages: 12,15,25,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
1 |
|
2 |
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RNA in situ |
1 |
|
2 |
cDNA source data(12)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(14)
cDNA(13)
Primer pair(1)
Microarray probesets(2)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR002077 |
Voltage-dependent calcium channel, alpha-1 subunit |
| IPR005447 |
Voltage-dependent calcium channel, N-type, alpha-1 subunit |
| IPR005821 |
Ion transport |
| IPR014873 |
Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
| IPR018249 |
EF-HAND 2 |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:16589
Coppola T et al.,
"Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization."
FEBS Lett 1994 Jan 24;338(1):1-5
(Latest)
J:154243
Fischer M et al.,
"P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons."
Mol Cell Neurosci 2009 Oct;42(2):134-41
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All references(43)
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Other
accession IDs
|
MGD-MRK-1803, MGI:2139282, MGI:2139293, MGI:2139419
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Analysis Tools
MGI BioMart
