Symbol
Name
ID
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Synonyms
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alpha(1B), Cav2.2, Cchn1a
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(26)
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Alleles
and
phenotypes
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All alleles(4) :
Targeted, knock-out(1)
Targeted, other(3)
| Mice deficient in this gene exhibit defects in nociception, memory and learning. They also exhibit hyperactive and hyperaggressive behaviors as well as defects in the the sleep-wake cycle. Deficits in the sympathetic nervous system results in defects in circulatory regulation. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(883 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (5 records)
Data Summary:
Assays (2)
Results (4)
Tissues (4)
Theiler Stages: 12,15,25,28
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Assay Type |
Assays |
|
Results |
| |
RT-PCR |
1 |
|
2 |
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RNA in situ |
1 |
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2 |
cDNA source data(12)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
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All nucleic(14)
cDNA(13)
Primer pair(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR002077 |
Voltage-dependent calcium channel, alpha-1 subunit |
| IPR005447 |
Voltage-dependent calcium channel, N-type, alpha-1 subunit |
| IPR005821 |
Ion transport |
| IPR018249 |
EF-HAND 2 |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:16589
Coppola T et al.,
"Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization."
FEBS Lett 1994 Jan 24;338(1):1-5
(Latest)
J:147982
Sehic A et al.,
"Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse."
Eur J Oral Sci 2009 Apr;117(2):93-104
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All references(42)
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Other
accession IDs
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MGD-MRK-1803, MGI:2139282, MGI:2139293, MGI:2139419
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