Symbol
Name
ID
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Synonyms
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8430418G19Rik, C79217, Cacnl1a2, Cav1.3alpha1, Cchl1a, Cchl1a2, D-LTCC
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(25)
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Alleles
and
phenotypes
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All alleles(7) :
Targeted, knock-out(2)
Gene trapped(5)
| Homozygotes for targeted mutations exhibit small size, hypoinsulinemia, glucose intolerance, decreased number and size of pancreatic islets, deafness with degeneration of hair cells, bradycardia, and arrhythmia. |
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Polymorphisms
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RFLP(3)
SNPs within 2kb(1830 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (8 records)
Data Summary:
Assays (5)
Results (16)
Tissues (5)
Images (4)
Theiler Stages: 15,20,23,25,28
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Assay Type |
Assays |
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Results |
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Western blot |
1 |
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2 |
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RT-PCR |
4 |
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14 |
cDNA source data(36)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
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All nucleic(42)
cDNA(37)
Primer pair(4)
Other(1)
Antibodies(1)
Microarray probesets(3)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR002077 |
Voltage-dependent calcium channel, alpha-1 subunit |
| IPR005446 |
Voltage-dependent calcium channel, L-type, alpha-1 subunit |
| IPR005452 |
Voltage-dependent calcium channel, L-type, alpha-1D subunit |
| IPR005821 |
Ion transport |
| IPR014873 |
Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:26177
Perez-Reyes E et al.,
"Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes."
J Biol Chem 1990 Nov 25;265(33):20430-6
(Latest)
J:142607
Mancarella S et al.,
"Impaired Ca2+ homeostasis is associated with atrial fibrillation in the alpha1D L-type Ca2+ channel KO mouse."
Am J Physiol Heart Circ Physiol 2008 Nov;295(5):H2017-24
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All references(50)
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Other
accession IDs
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MGD-MRK-1798, MGD-MRK-1799, MGD-MRK-18686, MGI:1921774, MGI:2145861
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