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Ctnna1 Gene Detail
 Symbol
Name
ID
Ctnna1
catenin (cadherin associated protein), alpha 1
MGI:88274


Nomenclature History
Synonyms 2010010M04Rik, alpha E catenin, alpha(E)-catenin, Catna1
Genetic Map
Chromosome 18
11.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr18:35278566-35414427 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ctnna1 ± 2 cM)
Protein SuperFamily: alpha-catenin
TreeFam: TF313686
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000037815 Ensembl Gene Model | MGI Sequence Detail 135862 C57BL/6J ± Kb
transcript NM_009818 RefSeq | MGI Sequence Detail 3713 129/Sv
polypeptide P26231 UniProt | EBI | MGI Sequence Detail 906 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes
All alleles(133) : Targeted, other(1) Gene trapped(131) Spontaneous(1)
Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. A conditional knockout in surface epithelium results in defects in hair follicle development and epidermal morphogenesis.
Polymorphisms RFLP(1) SNPs within 2kb(357 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process apical junction assembly, cell adhesion...
Component actin cytoskeleton, adherens junction...
Function actin filament binding, cadherin binding...
External Resources: FuncBase
Expression Literature Summary: (31 records)
Data Summary: Assays (6)    Results (119)    Tissues (111)    Images (30)
Theiler Stages: 3,4,5,20,22,24,25,26,28
  Assay Type Assays   Results
      Western blot 1   1
      RNA in situ 1   93
      Immunohistochemistry 4   25
cDNA source data(454)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(459) cDNA(458) Primer pair(1) Antibodies(4)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000037815
Consensus CDS Project CCDS29139.1
UniGene 18962
PDB 1DOV, 1DOW, 1L7C
DFCI TC1573949, TC1605261, TC1640468
NIA Mouse Gene Index U018559
Entrez Gene 12385
International Mouse Knockout Project Status Ctnna1
Protein
domains
InterPro ID Description
IPR000633 Vinculin, conserved site
IPR001033 Alpha-catenin
IPR006077 Vinculin/alpha-catenin
Graphical View of Protein Domain Structure
References
(Earliest) J:37373 Ozawa M et al., "The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species." EMBO J 1989 Jun;8(6):1711-7
(Latest) J:153566 Fujimura N et al., "Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium." Dev Biol 2009 Oct 1;334(1):31-45
All references(61)
Other
accession IDs
MGD-MRK-1773, MGI:1913796, MGI:2147175, MGI:2147284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory