Symbol
Name
ID
|
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(53)
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Alleles
and
phenotypes
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All alleles(24) :
Targeted, knock-out(5)
Targeted, other(16)
Gene trapped(3)
| Homozygotes for targeted null alleles exhibit sensory neuron losses affecting coordination, balance, hearing, taste, and breathing, cerebellar abnormalities, increased sympathetic neuron number, and postnatal lethality. Carriers show mild defects. |
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Polymorphisms
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SNPs within 2kb(210 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (50 records)
Data Summary:
Assays (9)
Results (194)
Tissues (106)
Images (18)
Theiler Stages: 22,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
4 |
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23 |
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RNA in situ |
2 |
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164 |
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Immunohistochemistry |
1 |
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3 |
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Northern blot |
2 |
|
4 |
cDNA source data(13)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
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All nucleic(24)
Genomic(4)
cDNA(13)
Primer pair(4)
Other(3)
Antibodies(1)
Microarray probesets(3)
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Other database
links
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| Ensembl Gene Model |
ENSMUSG00000048482 |
| DoTS |
DT.101345200, DT.101357751, DT.110686956, DT.40168441, DT.486320, DT.97412972, DT.97412973, DT.97412975, DT.97412976 |
| UniGene |
1442 |
| DFCI |
TC1586803, TC1608965, TC1671304 |
| NIA Mouse Gene Index |
U002219 |
| Entrez Gene |
12064 |
| VEGA Gene Model |
OTTMUSG00000015122 |
| International Mouse Knockout Project Status |
Bdnf |
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Protein
domains
|
| InterPro ID |
Description |
| IPR002072 |
Nerve growth factor-related |
| IPR019846 |
Nerve growth factor conserved site |
| IPR020408 |
Nerve growth factor-like |
| IPR020430 |
Brain-derived neurotrophic factor |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:14600
Barde YA et al.,
"Purification of a new neurotrophic factor from mammalian brain."
EMBO J 1982;1(5):549-53
(Latest)
J:154254
Oo TF et al.,
"Brain-derived neurotrophic factor regulates early postnatal developmental cell death of dopamine neurons of the substantia nigra in vivo."
Mol Cell Neurosci 2009 Aug;41(4):440-7
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All references(300)
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Other
accession IDs
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MGD-MRK-1534
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