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Alox5 Gene Detail
 Symbol
Name
ID
Alox5
arachidonate 5-lipoxygenase
MGI:87999


Nomenclature History
Synonyms 5-LO, 5-LOX, 5LO, 5LX
Genetic Map
Chromosome 6
53.2 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr6:116360089-116411196 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat; hamster, golden    (Mammalian Orthology)
Comparative Map (Mouse/Human Alox5 ± 2 cM)
Protein SuperFamily: arachidonate 5-lipoxygenase
TreeFam: TF105320
Sequences
Representative Sequences Length Strain/Species Flank
genomic 11689 NCBI Gene Model | MGI Sequence Detail 51108 C57BL/6J ± Kb
transcript NM_009662 RefSeq | MGI Sequence Detail 2827 C57BL/6
polypeptide P48999 UniProt | EBI | MGI Sequence Detail 674 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(2) Targeted, other(1)
Polymorphisms RFLP(1) SNPs within 2kb(328 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(18)
Process inflammatory response, leukotriene biosynthetic process...
Component cytoplasm, membrane...
Function arachidonate 5-lipoxygenase activity, calcium ion binding...
External Resources: MouseFunc
Expression cDNA source data(31)
External Resources: GEO 
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(31)
Microarray probesets(1)
Pathways
divinyl ether biosynthesis II (13-LOX)
13-LOX and 13-HPL pathway
Other database
links
EC 1.13.11.34
Ensembl Gene Model ENSMUSG00000025701
DoTS DT.110483153, DT.490623, DT.94294351, DT.97338506, DT.99853905
UniGene 41072
DFCI TC1582829, TC1640626, TC1648673, TC1648945
Entrez Gene 11689
International Mouse Knockout Project Status Alox5
Protein
domains
InterPro ID Description
IPR000907 Lipoxygenase
IPR001024 Lipoxygenase, LH2
IPR001885 Lipoxygenase, mammalian
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013819 Lipoxygenase, C-terminal
IPR020833 Lipoxygenase, iron binding site
IPR020834 Lipoxygenase, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:19332 Funk CD et al., "Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions." Ann N Y Acad Sci 1994 Apr 18;714():253-8
(Latest) J:153174 Poeckel D et al., "Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in apoe knock-out mice." J Biol Chem 2009 Jul 31;284(31):21077-89
All references(70)
Other
accession IDs
MGD-MRK-1286, MGI:2141502

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory