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Akt1 Gene Detail
 Symbol
Name
ID
Akt1
thymoma viral proto-oncogene 1
MGI:87986

Nomenclature History
Synonyms Akt, PKB, PKB/Akt, PKBalpha
Genetic Map
Chromosome 12
57.0 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM
 
Mapping data( 1)

Sequence Map
Chr12:113892032-113913095 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Akt1 ± 2 cM)
Protein SuperFamily: RAC serine/threonine-protein kinase
TreeFam: TF102004
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020941 VEGA Gene Model | MGI Sequence Detail 21064 C57BL/6J ± Kb
transcript NM_009652 RefSeq | MGI Sequence Detail 2707 C57BL/6
polypeptide P31750 UniProt | EBI | MGI Sequence Detail 480 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes 		All alleles(7) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(3)
Mutant homozygotes are smaller than sibs due to retarded prenatal and postnatal growth and exhibit increased apopotosis and decreased lifespan with genotoxic stress. Mice are fertile, but males have attenuated spermatogenesis and abnormal testes.
Phenotype Images (3)  
Polymorphisms RFLP(1) SNPs within 2kb(106 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process activation-induced cell death of T cells, anagen...
Component cytoplasm, cytosol...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (91 records)
Data Summary: Assays (9)    Results (146)    Tissues (63)    Images (6)
Theiler Stages: 19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 5   46
      RT-PCR 2   92
      Immunohistochemistry 2   8
cDNA source data(215)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(221) Genomic(2) cDNA(215) Primer pair(3) Other(1) Antibodies(6)
Microarray probesets(3)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000001729
DoTS DT.101403566, DT.535357, DT.94188038, DT.94396697
Consensus CDS Project CCDS26194.1
UniGene 6645
DFCI TC1574276, TC1582836, TC1596841, TC1668174
NIA Mouse Gene Index U034387
Entrez Gene 11651
VEGA Gene Model OTTMUSG00000020941
International Mouse Knockout Project Status Akt1
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR001849 Pleckstrin homology
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR011993 Pleckstrin homology-type
IPR015744 Rac serine/threonine kinase
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR017892 Protein kinase, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:455 Cho M et al., "A linkage map of distal mouse chromosome 12." Mamm Genome 1991;1(1):30-6
(Latest) J:156391 Buzzi F et al., "Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass." Mol Cell Biol 2010 Feb;30(3):601-12
All references(281)
Other
accession IDs 		MGD-MRK-1257
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory