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Adh1 Gene Detail
 Symbol
Name
ID
Adh1
alcohol dehydrogenase 1 (class I)
MGI:87921

Nomenclature History
STS D3Nds9
Synonyms Adh-1, Adh-1-t, Adh-1e, Adh-1t, ADH-AA, Adh1-e, Adh1-t, Adh1tl, class I alcohol dehydrogenase
Genetic Map
Chromosome 3
71.2 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 15)

Sequence Map
Chr3:137923955-137953662 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Adh1 ± 2 cM)
Protein SuperFamily: alcohol dehydrogenase
TreeFam: TF300429
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000034747 VEGA Gene Model | MGI Sequence Detail 29708 C57BL/6J ± Kb
transcript NM_007409 RefSeq | MGI Sequence Detail 1348 FVB/N
polypeptide P00329 UniProt | EBI | MGI Sequence Detail 375 Not Applicable
For the selected sequences
All sequences(40)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(2)
Homozygotes for targeted null mutations exhibit impaired metabolism of (and sensitivity to) ethanol and retinol.
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(179 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process behavioral response to ethanol, ethanol catabolic process...
Component cytoplasm, intracellular...
Function alcohol dehydrogenase (NAD) activity, binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (16 records)
Data Summary: Assays (7)    Results (50)    Tissues (26)    Images (12)
Theiler Stages: 1,3,4,9,11,13,15,17,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 3   32
      RNA in situ 3   13
      Northern blot 1   5
cDNA source data(17)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(33) Genomic(9) cDNA(18) Primer pair(6)
Microarray probesets(2)
Pathways
phenylalanine degradation III
oxidative ethanol degradation I
Other database
links
EC 1.1.1.1
Ensembl Gene Model ENSMUSG00000074207
DoTS DT.101714693, DT.537179, DT.97335280
Consensus CDS Project CCDS17867.1
DFCI TC1573340
NIA Mouse Gene Index U024699, U116865
Entrez Gene 11522
VEGA Gene Model OTTMUSG00000034747
International Mouse Knockout Project Status Adh1
Protein
domains
InterPro ID Description
IPR002085 Alcohol dehydrogenase superfamily, zinc-containing
IPR002328 Alcohol dehydrogenase, zinc-containing, conserved site
IPR011032 GroES-like
IPR013149 Alcohol dehydrogenase, zinc-binding
IPR013154 Alcohol dehydrogenase GroES-like
IPR016040 NAD(P)-binding domain
Graphical View of Protein Domain Structure
References
(Earliest) J:6249 Holmes RS, "Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3." Biochem Genet 1979 Jun;17(5-6):461-72
(Latest) J:129602 O'Shaughnessy PJ et al., "Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis." Endocrinology 2007 Jun;148(6):2914-24
All references(62)
Other
accession IDs 		MGD-MRK-1111, MGD-MRK-1112, MGD-MRK-1113, MGD-MRK-1115, MGD-MRK-1120, MGD-MRK-1121, MGD-MRK-1123, MGD-MRK-1124, MGI:2139643, MGI:87922, MGI:87924, MGI:87925
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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