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Acat1 Gene Detail
 Symbol
Name
ID
Acat1
acetyl-Coenzyme A acetyltransferase 1
MGI:87870

Nomenclature History
Synonyms 6330585C21Rik, Acat
Genetic Map
Chromosome 9
30.0 cM, cytoband C-D
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr9:53389805-53418447 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rabbit, European; rat; hamster, golden    (Mammalian Orthology)
Comparative Map (Mouse/Human Acat1 ± 2 cM)
Protein SuperFamily: acetyl-CoA acetyltransferase
TreeFam: TF300650
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000032047 Ensembl Gene Model | MGI Sequence Detail 28643 C57BL/6J ± Kb
transcript NM_144784 RefSeq | MGI Sequence Detail 3373 C57BL/6
polypeptide Q8QZT1 UniProt | EBI | MGI Sequence Detail 424 Not Applicable
For the selected sequences
All sequences(23)
Alleles
and
phenotypes 		All alleles(4) : Gene trapped(4)
Polymorphisms RFLP(3) SNPs within 2kb(44 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process metabolic process
Component mitochondrial inner membrane, mitochondrion...
Function acetyl-CoA C-acetyltransferase activity, acyltransferase activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
cDNA source data(248)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(254) Genomic(1) cDNA(251) Other(2)
Microarray probesets(4)
Pathways
acetoacetate degradation (to acetyl CoA)
2-methylbutyrate biosynthesis
glutaryl-CoA degradation
3-hydroxypropionate/4-hydroxybutyrate cycle
mevalonate pathway
isoleucine degradation
ketone oxidation
ketogenesis
superpathway of cholesterol biosynthesis
tryptophan degradation III (eukaryotic)
Other database
links
EC 2.3.1.9
Ensembl Gene Model ENSMUSG00000032047
DoTS DT.102558494, DT.87069871, DT.94299926
Consensus CDS Project CCDS23184.1
UniGene 293233
DFCI TC1573563
NIA Mouse Gene Index U030874
Entrez Gene 110446
International Mouse Knockout Project Status Acat1
Protein
domains
InterPro ID Description
IPR002155 Thiolase
IPR016038 Thiolase-like, subgroup
IPR016039 Thiolase-like
IPR020610 Thiolase, active site
IPR020613 Thiolase, conserved site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020616 Thiolase, N-terminal
IPR020617 Thiolase, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:8321 Leader DP et al., "Isolation and characterization of cDNA clones from mouse skeletal muscle actin mRNA." DNA 1986 Jun;5(3):235-8
(Latest) J:154874 Huttunen HJ et al., "Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway." FASEB J 2009 Nov;23(11):3819-28
All references(25)
Other
accession IDs 		MGD-MRK-1027, MGD-MRK-1028, MGI:2443107
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory