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Acadl Gene Detail
 Symbol
Name
ID
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
MGI:87866

Nomenclature History
Synonyms C79855, LCAD
Genetic Map
Chromosome 1
27.3 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr1:66877413-66909851 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Acadl ± 2 cM)
Protein SuperFamily: acyl-CoA dehydrogenase
TreeFam: TF105054
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000026221 VEGA Gene Model | MGI Sequence Detail 32439 C57BL/6J ± Kb
transcript NM_007381 RefSeq | MGI Sequence Detail 1892 C57BL/6
polypeptide P51174 UniProt | EBI | MGI Sequence Detail 430 Not Applicable
For the selected sequences
All sequences(32)
Alleles
and
phenotypes 		All alleles(1) : Targeted, knock-out(1)
Homozygous mutation of this gene results in reduced litter size, sudden death between 2-14 weeks of age, reduced serum glucose levels, lipid accumulation in the liver and heart, and cardiomyopathy. Heterozygous mutant animals exhibit reduced litter size.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (1)  
Polymorphisms SNPs within 2kb(201 from dbSNP Build 128)   SNPs within 2kb including multiple locations(203)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process carnitine catabolic process, carnitine metabolic process, CoA-linked...
Component mitochondrion
Function acyl-CoA dehydrogenase activity, FAD binding...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (3)    Tissues (2)    Images (1)
Theiler Stages: 21,22
  Assay Type Assays   Results
      RNA in situ 2   3
cDNA source data(266)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(269) cDNA(268) Primer pair(1)
Microarray probesets(3)
Other database
links
EC 1.3.99.13
Ensembl Gene Model ENSMUSG00000026003
DoTS DT.536956
Consensus CDS Project CCDS15023.1
UniGene 2445
DFCI TC1573592, TC1724864
NIA Mouse Gene Index U021424
Entrez Gene 11363
VEGA Gene Model OTTMUSG00000026221
International Mouse Knockout Project Status Acadl
Protein
domains
InterPro ID Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR006090 Acyl-CoA oxidase/dehydrogenase, type 1
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR006092 Acyl-CoA dehydrogenase, N-terminal
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase
IPR013764 Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:25568 Hall CL et al., "Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria." Arch Biochem Biophys 1976 Dec;177(2):402-14
(Latest) J:154719 Cox KB et al., "Cardiac hypertrophy in mice with long-chain acyl-CoA dehydrogenase or very long-chain acyl-CoA dehydrogenase deficiency." Lab Invest 2009 Dec;89(12):1348-54
All references(25)
Other
accession IDs 		MGD-MRK-1023, MGI:2138138, MGI:2138418, MGI:2138684
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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