References
Query Results -- Details
MGI Accession ID: MGI:61802
J Number: J:13620
Title: Possible allelism of roan and freckled
Authors: Lyon MF; Glenister PH
Journal: Mouse News Lett
Volume: 48
Issue:
Date: 1973
Year: 1973
Pages: 31
Review Status: Unreviewed
Abstract:
Full text of MNL contribution: 3. Possible allelism of roan and freckled. M.C. Green (MNL 44:30) suggested that Rn and Fkl (both in chromosome 14) might be allelic, but it has proved very difficult to test this point because of the variability of the mottling which each gene causes. It is now clear that Rn and Fkl are not identical. When crossed on to strain 101/H, Fkl gives a very llght-coloured coat with almost no wild-type patches, whereas Rn, after 3 crosses t o 101/H, gives a near wild-type coat with a few small light-coloured spots. Rn/+ Fkl/+ double heterozygotes are very variable, and not certainly distinguishable from single heterozygotes, but among segregating litters from Rn/+ Fkl/+, Rn and Fkl young can be distinguished. No evidence of crossing-over between Rn and Fkl has yet been found, but owing to normal overlapping by Rn and variability of Rn/+ Fk1/+ this evidence would be difficult to obtain. It is thus still uncertain whether Rn and Fkl are allelic or a closely linked gene pair, and it is suggested that the gene symbols should remain unchanged. (Lyon and Glenister)
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