References
Query Results -- Details
MGI Accession ID: MGI:61619
J Number: J:13426
Title: Dominant mutation resembling Mi
Authors: Stelzner KF
Journal: Mouse News Lett
Volume: 31
Issue:
Date: 1964
Year: 1964
Pages: 40-41
Review Status: Unreviewed
Abstract:
Full text of MNL contribution: Research news: l. Dominant mutation resembling Mi - series alleles. A new dominant appeared in one offspring of a male.that had received gamma irradiation to spermatogonia. Heterozygotes have slightly diluted fur and pale, pinkish ears and tails. A white belly streak and/or white head spot is often present. Eyes of heterozygotes show reduced- pigmentation at birth (resembling b/b) but appear full-colored in adults. Homozygous animals have white fur. Eyes may be absent; or perhaps they are so greatly reduced in size and pigment that they appear to be absent. The eyelids never open. Incisors often fail to erupt or are poorly formed. Animals with this condition usually die after weaning unless fed powdered food. Fertility of heterozygotes appears normal. Homozygous males are fully fertile, but of six homozygous females tested, all have proved sterile. This mutant appears to resemble mi in some ways and Miwh in others. Thus, our heterozygotes are like Miwh/+ and unlike mi/+ in showing dilution of fur in addition to eye pigment reduction and white spotting. Our homozygotes, on the other hand, resemble mi/mi rather than Miwh/Miwh whose eyes are not near-absent. Should allelism tests with mi-locus genes prove positive, we propose the symbol Mior. (Stelzner)
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