References
Query Results -- Details
MGI Accession ID: MGI:54276
J Number: J:5799
Other Accession IDs:
Title: Effect of a coat color locus on kidney lysosomal glycosidases in the house mouse.
Authors: Hakansson EM; Lundin LG
Journal: Biochem Genet
Volume: 15
Issue: 1-2
Date: 1977 Feb
Year: 1977
Pages: 75-85
Review Status: Peer Reviewed
Abstract:
Activities of three lysosomal glycosidases, beta-galactosidase, beta-glucuronidase, and N-acetyl-beta-hexosaminidase, have been shown to differ in bf/bf and bf/+ mice. Thus bf/bf mice usually have much higher activities of these enzymes in their kidney cells than bf/+ animals. There seem, however, to be some exceptions to this general pattern, especially for galactosidase of females from the C57BL/6J strain. A likely interpretation of the difference is that the bf locus has pleiotropic effects. An alternative explanation, less likely, is that a gene closely linked to bf is involved. There is also a differential response to dihydrotestosterone in different groups of mice reflected in activity changes of the three enzymes.
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