References
Query Results -- Details
MGI Accession ID: MGI:54254
J Number: J:5777
Other Accession IDs:
Title: Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse.
Authors: Rowe DW; McGoodwin EB; Martin GR; Grahn D
Journal: J Biol Chem
Volume: 252
Issue: 3
Date: 1977 Feb 10
Year: 1977
Pages: 939-42
Review Status: Peer Reviewed
Abstract:
Inbred mice bearing certain alleles at the Mottled locus have defects in connective tissue which result in weakness of skin and of blood vessels. Previous studies have established that cross-links in collagen and elastin are decreased in these animals due to impaired formation of lysine-derived aldehydes. Lysyl oxidase activity in extracts of skin is markedly lower in those prepared from affected animals than control mice. An inhibitor of lysyl oxidase is present in equal amounts in affected and control skins and does not account for diminished activity found in affected animals.
Additional Information:
