References
Query Results -- Details
MGI Accession ID: MGI:54218
J Number: J:5741
Other Accession IDs:
Title: The developmental analysis of an embryonic lethal (C6H) in the mouse.
Authors: Lewis SE; Turchin HA; Gluecksohn-Waelsch S
Journal: J Embryol Exp Morphol
Volume: 36
Issue: 2
Date: 1976 Oct
Year: 1976
Pages: 363-71
Review Status: Peer Reviewed
Abstract:
A development study of the effects of the C6H allele at the albino locus has identified the C6H homozygote as an early postimplantation lethal. Homozygous C6H embryos can first be recognized at 6 1/2-7 days of gestation by abnormalities of the ectoplacental and parietal endodern. At 7 1/2 days, mutant embryos appear severely retarded with obvious abnormalities in all germ layers. All C6H homozygotes are dead and resorbed by 8 days of development. It is proposed that the mutation interferes with the normal differentiation of the parietal endoderm, ectoplacental cone and extra-embryonic ectoderm of the egg cyclinder.
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