References
Query Results -- Details
MGI Accession ID: MGI:54076
J Number: J:5599
Other Accession IDs:
Title: Spleen cells transmit osteopetrosis in mice.
Authors: Walker DG
Journal: Science
Volume: 190
Issue: 4216
Date: 1975 Nov 21
Year: 1975
Pages: 785-7
Review Status: Peer Reviewed
Abstract:
Osteopetrosis was induced in lethally irradiated, normal mice of grey-lethal and microphthalmic stocks by cell infusions prepared from the spleens of osteopetrotic littermates. Failure of skeletal remodeling became evident within a few weeks after transplantation as calcified cartilage and bone accumulated excessively in the active metaphyses of the long bones. The massive lesions produced were extensively infiltrated with abnormal osteoclasts.
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