|
|
| Nomenclature |
|
Symbol:
|
Il2m1
|
|
Name:
|
interleukin 2;
mutation 1
|
|
MGI ID: |
MGI:4352594 |
|
Gene:
|
Il2
Location:
Chr3:37019445-37024881 bp, - strand
Genetic Position: Chr3,
19.2 cM, cytoband B-C
|
|
Mutation
origin |
|
Strain of Origin:
|
multiple strains
|
|
Mutation
description |
|
Allele
Type: |
Spontaneous |
|
Mutation: |
Undefined |
| |
This hypoactive polymorphism, found in MRL/MpJ, SJL/J, and NOD/ShiLtJ inbred strains, includes a smaller polyglutamine tract predicted to shorten the first alpha helix, which forms part of the IL2 receptor binding site. (J:75331) |
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Phenotype
summary
|
|
Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
|
Key:
|
| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
|
|
|
|
|
Phenotypic
data by
genotype
|
|
Phenotypic Data by Genotype
(show or
hide all phenotypic details)
|
| Genotype | Allelic Composition | Genetic Background |
|
  hm1
|
Il2m1/Il2m1 |
MRL/MpJ |
hematopoietic system immune system |
|
|
| References |
|
Original: |
J:75331
Choi Y et al.,
"Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice."
Eur J Immunol 2002 Mar;32(3):677-85
|
|
All: |
1 reference(s)
|
|
