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| Nomenclature |
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Symbol:
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Tg(Camk2a-UBB*)3413-1Fwvl
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Name:
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transgene insertion 3413-1, FW van Leeuwen
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MGI ID: |
MGI:3843483 |
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Synonyms: |
UBB+1 3413, UBB+1 3413 |
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Transgene:
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Tg(Camk2a-UBB*)3413-1Fwvl
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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A transgenic construct containing cDNA encoding the mutant human ubiquitin B, UBB+1 sequence (in the +1 reading frame), under the direction of the mouse Camk2a (calcium/calmodulin-dependent protein kinase II alpha) promoter was injected into fertilized C57BL/6 mouse eggs. Founder line 3413-1 with 13 copies of the transgene was subsequently established. mRNA levels for UBB+1 are 49% of endogenous Ubb mRNA levels. (J:147938) |
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Mouse strains and cell lines available from the
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:147938
Fischer DF et al.,
"Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin."
Neurobiol Aging 2009 Jun;30(6):847-63
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All: |
1 reference(s)
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