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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm2(SNCA*119)Djmo
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Name:
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gene trap ROSA 26, Philippe Soriano;
Targeted mutation 2, Darren Moore
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MGI ID: |
MGI:3840596 |
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Synonyms: |
ROSA26-a-synuclein C-terminal truncation variant (Syn119), ROSA26-Syn119, ROSA26-SynCT119Tg |
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Gene:
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Gt(ROSA)26Sor
Location:
unknown
Genetic Position: Chr6,
48.7 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:147331
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: |
Targeted (knock-in) |
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Mutation: |
Insertion |
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A targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a cDNA encoding the 119 amino acid C-terminal truncation of human alpha-synuclein associated with familial Parkinson's disease (Syn119 or SynCT119; encoding amino acids 1-119 of the full length protein), and a bovine polyadenylation signal. (J:147331, J:150777) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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1Conditionally targeted allele(s).
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Notes |
Authors state that 129/SvJ-derived embryonic stem cells were used.
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| References |
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Original: |
J:147331
Moore D,
"Generation of a conditional knockin allele expresing a truncated human alpha-synuclein (SNCA)"
MGI Direct Data Submission 2009;():
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All: |
2 reference(s)
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