|
|
| Nomenclature |
|
Symbol:
|
Tg(tetO-DISC1*)1001Plet
|
|
Name:
|
transgene insertion 1001, Mikhail Pletnikov
|
|
MGI ID: |
MGI:3838645 |
|
Synonyms: |
Tg(tetO/CMV-DISC1*)1001Plet, Tg(TRE-CMVhDISC1) |
|
Transgene:
|
Tg(tetO-DISC1*)1001Plet
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
C57BL/6 and SJL
|
|
Transgene
description |
|
Transgene
Type: |
Transgenic (random, expressed) |
|
Mutation: |
Insertion |
| |
The transgene construct was designed with the myc peptide tagged mutant human DISC1 (disrupted in schizophrenia 1) gene, under the control of tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequence and a cytomegalovirus minimal promoter. Founder line 1001, which showed strong expression, was established. A second line, line 70, shows weak expression of human DISC1. (J:146881) |
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Phenotype
summary
|
|
Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
|
Key:
|
| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
|
|
|
|
|
Phenotypic
data by
genotype
|
|
Phenotypic Data by Genotype
(show or
hide all phenotypic details)
|
|
|
|
| References |
|
Original: |
J:146881
Pletnikov MV et al.,
"Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia."
Mol Psychiatry 2008 Feb;13(2):173-86, 115
|
|
All: |
1 reference(s)
|
|
