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| Nomenclature |
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Symbol:
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mt-Trm1
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Name:
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mitochondrially encoded tRNA arginine;
mutation 1
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MGI ID: |
MGI:3831887 |
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Synonyms: |
10A |
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Gene:
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mt-Tr
Location:
ChrMT:9808-9875 bp, + strand
Genetic Position: ChrMT,
Syntenic
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Mutation
origin |
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Strain of Origin:
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various
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Nucleotide repeat expansion |
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The adenine repeat in the D stem is polymorphic with 10 adenines in this allele. (J:67312, J:97969) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  cx1
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Cdh23ahl/Cdh23ahl
mt-Trm1/? |
either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1 |
hearing/vestibular/ear |
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Notes |
This polymorphism is present in A/J, NZB/B1NJ, ALS/Lt and NOD/ShiLtJ. A variant with 9 adenines is found in NOD/ShiLtDvs, ALR/Lt and SKH2/J.
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| References |
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Original: |
J:67312
Johnson KR et al.,
"A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice."
Nat Genet 2001 Feb;27(2):191-4
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All: |
3 reference(s)
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