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| Nomenclature |
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Symbol:
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Itga4tm1Mshi
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Name:
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integrin alpha 4;
targeted mutation 1, Motomu Shimaoka
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MGI ID: |
MGI:3830623 |
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Synonyms: |
Itga4-R/AGFFKR |
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Gene:
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Itga4
Location:
Chr2:79095583-79173280 bp, + strand
Genetic Position: Chr2,
46.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:144092
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: |
Targeted (knock-in) |
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Mutations: |
Insertion, Nucleotide substitutions |
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Exon 28 was replaced with one in which nucleotide substitutions resulted in amino acid substitutions of GFFKA for GFFKR. This sequence is involved in the formation of a membrane-proximal salt bridge necessary for inactivation. A self-excising neo cassette was inserted upstream of exon 28 and subsequently deleted in chimeras. (J:144092) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:144092
Imai Y et al.,
"Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrins."
Blood 2008 Dec 15;112(13):5007-15
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All: |
1 reference(s)
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