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| Nomenclature |
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Symbol:
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Tg(Cyp21a1-Apoe)619Fet
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Name:
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transgene insertion 619, Fayanne Thorngate
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MGI ID: |
MGI:3822316 |
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Synonyms: |
Line 619 |
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Transgene:
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Tg(Cyp21a1-Apoe)619Fet
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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A construct containing approximately 6 kb of the mouse Cyp21a1 promoter attached to the mouse Apoe gene was used for injection into fertilized FVB/N oocytes. Ten independent founder lines were generated. Line 619 was donated to the Jackson Laboratory and is representative of low expressing Apoe lines (lines 619 and 620). Only adrenal expression of Apoe was detected for these lines with Line 619 having the lowest mRNA expression (1.6 pg Apoe mRNA per microgram of total RNA). Mice have only 1-2% of wild-type plasma Apoe protein level. (J:130658) |
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Mouse strains and cell lines available from the
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:130658
Thorngate FE et al.,
"Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice."
Arterioscler Thromb Vasc Biol 2000 Aug;20(8):1939-45
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All: |
1 reference(s)
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