ahl4<A/J> Spontaneous Allele Detail MGI Mouse (MGI:3807581)

ahl4^A/J
Spontaneous Allele Detail

Nomenclature

Symbol:	ahl4^A/J
Name:	age related hearing loss 4; A/J
MGI ID:	MGI:3807581
Gene:	ahl4 Location: unknown Genetic Position: Chr10, Syntenic

Mutation
origin

Strain of Origin:

A/J

Mutation
description

Allele Type:	Spontaneous
Inheritance:	Recessive

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any ahl4 Mutation:	2 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

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Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	hm2
hearing/vestibular/ear		√	√
decreased brainstem auditory evoked potential		√	√
increased susceptibility to age-related hearing loss		√	√
impaired hearing		√	√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
hm1	ahl4^A/J/ahl4^A/J	A/J
hearing/vestibular/ear decreased brainstem auditory evoked potential (J:139222) in A/J mice ABR thresholds at 16 and 32 kHz are elevated by 25 days of age and by 3 months of age the ABR thresholds are more than 50 dB above normal increased susceptibility to age-related hearing loss (J:139222) in A/J mice onset of hearing loss is found as early as 25 days of age and is much more severe at 6 months of age than that found in C57BL/6J impaired hearing (J:139222)
Genotype	Allelic Composition	Genetic Background
hm2	ahl4^A/J/ahl4^A/J	C57BL/6J-Chr 10^A/J/NaJ
hearing/vestibular/ear decreased brainstem auditory evoked potential (J:139222) relative to C57BL/6J controls, C57BL/6J-Chr 10/NaJ consomic mice have ABR thresholds only slightly higher at 3 months of age, but 30 dB higher at 6 months of age and 50 dB higher at 9 months of age increased susceptibility to age-related hearing loss (J:139222) the onset of hearing loss occurs earlier and progresses more rapidly than in C57BL/6J impaired hearing (J:139222) 16 kHz ABR thresholds average 30 dB higher than in C57BL/6J controls

References

Original:	J:139222 Zheng QY et al., "A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice." Neurobiol Aging 2008 Feb 13;():
All:	1 reference(s)

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