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| Nomenclature |
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Symbol:
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Trp53tm2Holl
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Name:
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transformation related protein 53;
targeted mutation 2, Monica Hollstein
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MGI ID: |
MGI:3794646 |
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Synonyms: |
p5372pro, Trp53tm1Moho |
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Gene:
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Trp53
Location:
Chr11:69393861-69405375 bp, + strand
Genetic Position: Chr11,
39.0 cM, cytoband B2-C
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:135505
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: |
Targeted (knock-in) |
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Mutation: |
Insertion |
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Exons 4 through 9 were replaced with corresponding exons from the human gene with a sequence variant in exon 4 that results in a proline at amino acid position 72. A floxed neo cassette used for selection was removed by cre mediated recombination. This mutation corresponds to the prevalent allele among humans of non-Northern European descent. (J:135505) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
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expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:135505
Reinbold M et al.,
"Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72."
Oncogene 2008 Apr 24;27(19):2788-94
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All: |
1 reference(s)
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