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| Nomenclature |
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Symbol:
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Tg(Prnp-TBP*)13Xjl
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Name:
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transgene insertion 13, Xiao-Jiang Li
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MGI ID: |
MGI:3772701 |
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Synonyms: |
TBP-13Q |
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Transgene:
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Tg(Prnp-TBP*)13Xjl
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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A transgenic construct containing the human TATA box binding protein, TBP, containing a 13 polyQ repeat expansion, under the control of the mouse prion protein promoter was injected into fertilized FVB/N mouse eggs. Founder line TBP-13Q was established. Western blot analysis could not distinguish between endogenous and mutant TBP protein. Immunoreactive TBP protein was not detected in 4 month old brains. (J:130775) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
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expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
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Tg(Prnp-TBP*)13Xjl/0 |
FVB/N-Tg(Prnp-TBP*)13Xjl |
life span/aging behavior/neurological nervous system 1One or more human genes may be associated with the human disease. The mouse genotype may involve mutations in orthologous genes, but the phenotype did not resemble the human disease.
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Disease
models
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1One or more human genes may be associated with the human disease. The mouse genotype may involve mutations in orthologous genes, but the phenotype did not resemble the human disease.
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| References |
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Original: |
J:130775
Friedman MJ et al.,
"Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration."
Nat Neurosci 2007 Dec;10(12):1519-28
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All: |
1 reference(s)
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