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| Nomenclature |
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Symbol:
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Tg(Prnp-TBP*)105Xjl
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Name:
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transgene insertion 105, Xiao-Jiang Li
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MGI ID: |
MGI:3772700 |
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Synonyms: |
TBP-105Q |
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Transgene:
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Tg(Prnp-TBP*)105Xjl
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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A transgenic construct containing the human TATA box binding protein, TBP, containing a 105 polyQ repeat expansion, under the control of the mouse prion protein promoter was injected into fertilized FVB/N mouse eggs. Founder line TBP-105Q was established. The 105 polyQ-expansion was detected in the cerebral cortex and cerebellum by Western blot analysis. (J:130775) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
Disease Model |
Tg(Prnp-TBP*)105Xjl/0 |
FVB/N-Tg(Prnp-TBP*)105Xjl |
life span/aging growth/size behavior/neurological nervous system skeleton 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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| References |
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Original: |
J:130775
Friedman MJ et al.,
"Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration."
Nat Neurosci 2007 Dec;10(12):1519-28
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All: |
1 reference(s)
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