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| Nomenclature |
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Symbol:
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Tg(tetO-Mcpt1)1Mrab
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Name:
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transgene insertion 1, Marlene Rabinovitch
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MGI ID: |
MGI:3772577 |
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Synonyms: |
RVCH+, TRE-RVCH-HA |
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Transgene:
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Tg(tetO-Mcpt1)1Mrab
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The transgene was designed with the tetracycline-responsive element (TRE; also called tet-operator or tetO) upstream of a rat vascular chymase (RVCH or Mcpt1) gene modified such that a human influenza hemagglutinin (HA) tag is added to the C terminus of mature RVCH protein. With ddition of dox expression of the RVCH-HA fusion protein can be completely abolished, reversing the hypertension phenotype. (J:70031) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:70031
Ju H et al.,
"Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice."
Proc Natl Acad Sci U S A 2001 Jun 19;98(13):7469-74
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All: |
1 reference(s)
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