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Tg(THY1-SNCA*A53T)M53Sud
Transgene Detail

Nomenclature
Symbol: Tg(THY1-SNCA*A53T)M53Sud
Name: transgene insertion M53, Thomas C Sudhof
MGI ID: MGI:3768388
Synonyms: M53, M70A53T
Transgene: Tg(THY1-SNCA*A53T)M53Sud   Location: unknown    
Transgene
origin
Strain of Origin: Not Specified
Transgene
description
Transgene Type: Transgenic (random, expressed)
Mutation: Insertion
  This transgenic strain carries the mouse Snca (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. (J:115193)
Find Mice (IMSR) Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms

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Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
tg1
 
tg2
  
life span/aging          
 N
  
nervous system          
 
Phenotypic
data by
genotype
Phenotypic Data by Genotype

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GenotypeAllelic CompositionGenetic Background
  
 tg1   
Tg(THY1-SNCA*A53T)M53Sud/0 involves: C57BL/6
  
 tg2   
Dnajc5tm1Sud/Dnajc5tm1Sud
Tg(THY1-SNCA*A53T)M53Sud/0
involves: 129S6/SvEvTac * C57BL/6
References
Original: J:115193 Chandra S et al., "Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration." Cell 2005 Nov 4;123(3):383-96
All: 2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/20/2009
MGI_4.31
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