Tg(THY1-SNCA)1Sud Transgene Detail MGI Mouse (MGI:3767987)

Tg(THY1-SNCA)1Sud
Transgene Detail

Nomenclature

Symbol:	Tg(THY1-SNCA)1Sud
Name:	transgene insertion 1, Thomas C Sudhof
MGI ID:	MGI:3767987
Synonyms:	LHS, Syn^htg
Transgene:	Tg(THY1-SNCA)1Sud Location: unknown

Transgene
origin

Strain of Origin:

Not Specified

Transgene
description

Transgene Type:	Transgenic (random, expressed)
Mutation:	Insertion
	The transgene expresses the human SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. (J:115193)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	tg1	tg2	tg3
behavior/neurological			√
behavior/neurological phenotype			N
abnormal grip strength			√
		tg1	tg2	tg3
life span/aging			N
life span/aging phenotype			N
		tg1	tg2	tg3
nervous system		√	√	√
nervous system phenotype			N
decreased motor neuron number		√
neurodegeneration				√
motor neuron degeneration		√
retinal photoreceptor degeneration			√
		tg1	tg2	tg3
vision/eye			√
retinal photoreceptor degeneration			√
abnormal vision			√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
tg1	Tg(THY1-SNCA)1Sud/0	involves: C57BL/6
nervous system decreased motor neuron number (J:115193) at 12-16 months, mice have only ~40% of motor neuron numbers in non-transgenic mice motor neuron degeneration (J:115193) mice show onset of motoneuron disease at ~5-6 months
Genotype	Allelic Composition	Genetic Background
tg2	Dnajc5^tm1Sud/Dnajc5^tm1Sud Tg(THY1-SNCA)1Sud/0	involves: 129S6/SvEvTac * C57BL/6
life span/aging life span-post-weaning/aging (J:115193) double mutants show rescue of lethality observed for Dnajc5-deficient mice; mice live >15 months behavior/neurological behavior/neurological phenotype (J:115193) transgenic Dnajc5-deficient mice have locomotor activity and righting ability like wild-type mice at all ages; ataxia is suppressed in mice abnormal grip strength (J:115193) in a grip test, mice can grip the mesh for the 2 minute duration of the test up to 30 days of age; at this time point, their eyesight begins to deteriorate and performance starts to decline nervous system nervous system phenotype (J:115193) gliosis and neuron degeneration observed in Dnajc5-null mice are rescued by transgene expression retinal photoreceptor degeneration (J:115193) mice show considerable photoreceptor degeneration vision/eye retinal photoreceptor degeneration (J:115193) mice show considerable photoreceptor degeneration abnormal vision (J:115193)
Genotype	Allelic Composition	Genetic Background
tg3	Tg(SOD1*G93A)1Gur/0 Tg(THY1-SNCA)1Sud/0	involves: 129S6/SvEvTac * C57BL/6 * SJL
nervous system neurodegeneration (J:115193) mice display neurodegeneration similar to Dnajc5-null mice

References

Original:	J:115193 Chandra S et al., "Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration." Cell 2005 Nov 4;123(3):383-96
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/20/2009 MGI_4.31 Web browser compatibility