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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm3(phiC31*)Sor
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 3, Philippe Soriano
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MGI ID: |
MGI:3766932 |
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Synonyms: |
R26phiC31lo |
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Gene:
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Gt(ROSA)26Sor
Location:
unknown
Genetic Position: Chr6,
48.7 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:128069
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Parent Cell Line:
| AK7.1 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: |
Targeted (knock-in) |
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Mutation: |
Insertion |
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A targeting construct with the SA-PhiC310pA-PGKneopA cassette, which contains the mouse codon-optimized site-specific recombinase PhiC31o sequence (with a C-terminal SV40 nuclear localization signal) driven by the phosphoglycerate kinase 1 (PGK) promoter, and bovine growth hormone polyadenylation (bpA) sequence was inserted into the Gt(ROSA)26Sor locus. PhiC31o-mediated recombination in mice carrying containing a sequence of interest flanked by attB and attP sites results in tissue-specific deletion of the targeted sequence. (J:128069) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Recombinase specificity
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Driver:
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Gt(ROSA)26Sor
Summary of all recombinase alleles
driven by Gt(ROSA)26Sor.
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MGI has not yet included tissue specificity data for this allele in any anatomical systems.
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:128069
Raymond CS et al.,
"High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells."
PLoS ONE 2007;2(1):e162
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All: |
1 reference(s)
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