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| Nomenclature |
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Symbol:
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Bchetm1Loc
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Name:
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butyrylcholinesterase;
targeted mutation 1, Oksana Lockridge
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MGI ID: |
MGI:3723049 |
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Synonyms: |
BChE KO, BChE- |
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Gene:
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Bche
Location:
Chr3:73439730-73512337 bp, - strand
Genetic Position: Chr3,
cytoband E3
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:124975
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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891bp of the gene is replaced with a neomycin selection cassette, including 485bp from the 3' end of intron 1 and 406bp from the 5' end of exon 2. The region encoding the entire signal peptide, the translation start site, and the first 102 amino acids of the mature protein is deleted. (J:124975) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
|
  hm1
Disease Model |
Bchetm1Loc/Bchetm1Loc |
involves: 129S1/Sv |
life span/aging reproductive system homeostasis/metabolism |
| Genotype | Allelic Composition | Genetic Background |
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ht2
|
Bchetm1Loc/Bche+ |
involves: 129S1/Sv |
life span/aging homeostasis/metabolism |
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Disease
models
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| References |
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Original: |
J:124975
Li B et al.,
"Production of the butyrylcholinesterase knockout mouse."
J Mol Neurosci 2006;30(1-2):193-5
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All: |
3 reference(s)
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