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| Nomenclature |
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Symbol:
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Tg(KRT14-rtTA)208Jek
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Name:
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transgene insertion 208, Jeffrey E Kudlow
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MGI ID: |
MGI:3717751 |
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Synonyms: |
K14-rtTA, K14-rtTA(X), K14-X, rtTA(X), X-linked K14-rtTA |
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Transgene:
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Tg(KRT14-rtTA)208Jek
Location:
unknown
Genetic Position: ChrX,
Syntenic
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The K14-rtTA transgene contains the 2.3 kb fragment of the human keratin 14 promoter that drives expression of the reverse tetracycline transactivator gene (rtTA), followed by an SV40 polyadenylation sequence. The 4.9 kb transgene was injected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder line 208 found to harbor the transgene on the X chromosome (also called founder line K14-X). Random X inactivation may result in mosaic rtTA expression patterns in female mice. The transgene when combined with mice carrying a gene under the control of a tetracycline-responsive promoter allows doxycycline-inducible gene expression in skin cells. (J:55970, J:96886) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
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expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:96886
Foster KW et al.,
"Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia."
Oncogene 2005 Feb 24;24(9):1491-500
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All: |
4 reference(s)
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