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| Nomenclature |
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Symbol:
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Tg(Prnp-ITM2B/APP695*40)1Emcg
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Name:
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transgene insertion 1, Eileen McGowan
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MGI ID: |
MGI:3710691 |
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Synonyms: |
BRI-Abeta1-40, BRI-Abeta40 |
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Transgene:
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Tg(Prnp-ITM2B/APP695*40)1Emcg
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C3H x C57BL/6)F1 X C57BL/6
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The BRI-Abeta40 transgene was generated with a mouse prion promoter upstream of a BRI-Abeta40 fusion construct, containing a cDNA sequence from human type 2 transmembrane protein (BRI or ITM2B) fused in-frame with a "wildtype APP695" cDNA sequence encoding amyloid-beta40 (Abeta40) at the furin-like cleavage site; the C-terminal 23 amino acid ABri peptide of BRI was replaced with the Abeta40 sequence. A single founder line with the highest Abeta40 plasma levels (line 1d) was donated to The Jackson Laboratory. Transgenic fusion protein expression approximates levels of endogenous mouse APP expression and is expressed in patterns characteristic of the Prnp promoter, with highest expression in cerebellar granule cells and hippocampus. Full length Abeta fusion protein is most highly expressed with processed Abeta40 peptide expressed at lower levels. (J:101023) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
Disease Model |
Tg(Prnp-ITM2B/APP695*40)1Emcg/0 |
involves: C3H * C57BL/6 |
nervous system other phenotype 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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| References |
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Original: |
J:101023
McGowan E et al.,
"Abeta42 is essential for parenchymal and vascular amyloid deposition in mice."
Neuron 2005 Jul 21;47(2):191-9
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All: |
4 reference(s)
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