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Tg(Tagln-rtTA)E1Jwst
Transgene Detail

Nomenclature
Symbol: Tg(Tagln-rtTA)E1Jwst
Name: transgene insertion E1, James West
MGI ID: MGI:3703755
Synonyms: SM22-rtTA
Transgene: Tg(Tagln-rtTA)E1Jwst   Location: unknown    
Transgene
origin
Strain of Origin: FVB/N
Transgene
description
Transgene Type: Transgenic (random, expressed)
Mutation: Insertion
  The transgene has the 488-bp fragment of the murine smooth muscle-specific SM22-alpha (Tagln or transgelin) promoter to drive expression of the reverse tetracycline transactivator gene (rtTA). (J:98898)
Find Mice (IMSR) Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms

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Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
tg1
  
cardiovascular system          
  
hematopoietic system          
  
muscle          
Phenotypic
data by
genotype
Phenotypic Data by Genotype

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GenotypeAllelic CompositionGenetic Background
  
 tg1   
Tg(Tagln-rtTA)E1Jwst/0
Tg(tetO-BMPR2*T504)1Jwst/0
involves: FVB/N
References
Original: J:98898 West J et al., "Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle." Circ Res 2004 Apr 30;94(8):1109-14
All: 5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/20/2009
MGI_4.31
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