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| Nomenclature |
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Symbol:
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Apba2tm1Sud
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Name:
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amyloid beta (A4) precursor protein-binding, family A, member 2;
targeted mutation 1, Thomas C Sudhof
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MGI ID: |
MGI:3697709 |
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Gene:
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Apba2
Location:
Chr7:71646592-71898756 bp, + strand
Genetic Position: Chr7,
25.5 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:115573
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: |
Targeted (Floxed/Frt) |
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Mutation: |
Insertion |
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The exon encoding amino acids 368-416 of the phosphotyrosine binding (PTB) domain is flanked by loxP sites. A single FRT site, the remnant of an FRT-flanked neomycin resistance cassette (neo) previously removed by crossing mice with the cassette to mice expressing Flp recombinase in the germline, is present in the downstream intron. (Retention of the neo cassette ablates expression of this gene in mice.) Immunoblot analysis of brain homogenates demonstrates that mice with this conditional mutation express the protein at wild-type levels. (J:115573) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
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Apba2tm1Sud/Apba2tm1Sud |
involves: 129S1/Sv * 129X1/SvJ |
phenotype not analyzed |
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| References |
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Original: |
J:115573
Ho A et al.,
"Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family."
J Neurosci 2006 Dec 13;26(50):13089-101
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All: |
2 reference(s)
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